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Caltech BioControl
We are investigating strategies for the engineering of biological systems
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Fiona A Chandra (Caltech)Login or register to post commentsnext meeting: Friday, February 5, 2010 - 9:00am at Steele Library
Promoter architecture and the evolvability of gene expression. Tirosh Itay (2009) J Biol.
Ophelia Venturelli (Caltech) created an eventLogin or register to post commentsFriday, January 15, 2010 - 9:00am at CDS Library (Steele 114)Here's the paper for tomorrow!
Elisa Franco (Caltech) created an eventFriday, November 27, 2009 - 10:00am at Steele LibraryWhat about this paper? If you have better ideas, let me know.
Login or register to post commentsWe did that one last year - it made it into the top of '07-'08. I'd suggest the new paper from Wingreen and Bassler (et al.). - Joshua K. Michener (Caltech) November 20, 2009 Comment deletedOh I must have missed that meeting! Thanks for pointing that out... - Elisa Franco (Caltech) November 28, 2009 Comment deleted- Ophelia Venturelli (Caltech)Login or register to post comments
Hey everyone-would it be okay if we shifted our meetings to 9am on Fridays? Let me know.
- Fiona A Chandra (Caltech) created an eventFriday, November 13, 2009 - 10:00am at CDS Library (Steele)
There will be bagels for breakfast!
Login or register to post commentsHow did this paper get into nature? Comment deleted - Elisa Franco (Caltech) created an eventLogin or register to post commentsFriday, October 30, 2009 - 10:00am at Steele Library
Paper about noise...
Molecular Systems Biology 5 Article number: 318 doi:10.1038/msb.2009.75
Published online: 13 October 2009
Citation: Molecular Systems Biology 5:318Listening to the noise: random fluctuations reveal gene network parameters
Brian Munsky1, Brooke Trinh2 & Mustafa Khammash3
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, October 7, 2009 - 10:30am at Steele Library
Potential date for starting our meetings again! I picked a random paper...
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, May 6, 2009 - 10:00am at Steele Library
signaling network
integration of multiple signals
EGF, Insulin MAPK cascades - Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, April 22, 2009 - 10:00am at Steele Library
Ultrasensitivity and molecular titration
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, April 8, 2009 - 10:00am at Steele Library
Stress transient transcriptional responses
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, April 8, 2009 - 10:00am at Steele Library
Modeling and experiments to understand mechanisms of gene regulation by sRNA in bacteria
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, March 18, 2009 - 10:00am at Steele Library
Control of Stem Cell Proliferation and Lineages
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, February 25, 2009 - 10:00am at Steele Library
Synthetic Controller to tune fitness tradeoffs.
Or, following up on our "Endy" topic with "Smolke" :P -F
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, February 18, 2009 - 10:00am at Steele Library
Drew Endy
* Is Drew the author or the topic?
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, January 28, 2009 - 10:00am at Steele Library
complex regulation of genes in yeast due to nucleosome positioning
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, December 3, 2008 - 10:00am at Steele Library
Quantitative models of gene expression in Yeast
- Elisa Franco (Caltech) created an eventLogin or register to post commentsWednesday, November 19, 2008 - 10:00am at Steele Library
* Activity motifs
* principles of timing
* transcriptional control
* yeast
* metabolic networksComments:
Promising, but ultimately disappointing. The curve fitting to the mRNA data was not convincing (the shape of the data did not match the fit). Measurements (mRNA and ChIP-chip in particular) should probably have large error bars, bringing fine distinctions in timing or affinity into question. Time resolution was also questionable - the first measurement was taken at 15 minutes, but differences in activation time of 3 minutes vs. 4 minutes were treated as significant. No data was presented to support the claim on correlation between binding affinity motifs and transcriptional activation motifs, and the conclusions were presented in a confusing fashion (why claim that 20/48 data sets showed correlation, rather than breaking things out by individual motifs?).