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Caltech Geobiology : Related Papers
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Jena Johnson (Caltech)Login or register to post commentsAny interest in looking into the nitrogen cycle 2.5 billion years ago?
Login or register to post commentsFrom the author's summary: "Effects of mutations can change under different genetic backgrounds or environmental factors, also known as epistasis and genotype-by-environment interactions (G×E), respectively. Though epistasis and G×E are traditionally treated as distinct phenomena, our study of a beneficial mutation highlights their commonality." - Anne Dekas (Caltech) November 5, 2009 Comment deleted
Jake V. Bailey (University of Minnesota, Twin Cities) is following 1 new article in Caltech Geobiology : Related PapersLogin or register to post comments
Login or register to post commentsAnother mechanism by which synonymous mutations may affect protein function is by altering the kinetics of protein folding. Researchers have proposed that synonymous substitutions that change a codon read by an abundant tRNA to a codon read by a rare tRNA could
http://feeds.nature.com/~r/chemistry/rss/the_sceptical_chymist_with_comm...
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...when it specifies a different fold! At least that's the latest word from Kimchi-Sarfaty et. al., who reported in the Jan 26 issue of Science that a supposedly "silent" mutation in the multidrug resistance gene MDR1 changes the function of the encoded protein.
http://www.gnxp.com/blog/2007/02/when-is-synonymous-sequence-not.php
