Another mechanism by which synonymous mutations may affect protein function is by altering the kinetics of protein folding. Researchers have proposed that synonymous substitutions that change a codon read by an abundant tRNA to a codon read by a rare tRNA could

http://feeds.nature.com/~r/chemistry/rss/the_sceptical_chymist_with_comm...

A "silent" polymorphism in the MDR1 gene changes substrate specificity. Kimchi-Sarfaty C (2007) Science.
January 22, 2009